FAQ: What Is The Biological Function Of The Bicoid Gene Product See Section 21.3?

It regulates the transcription of RNA and the translation of DNA.

What is the role of the bicoid protein?

Bicoid (Bcd) protein distributes in a concentration gradient that organizes the anterior/posterior axis of the Drosophila embryo.

What is the bicoid gene product?

Bicoid is the protein product of a maternal-effect gene unique to flies of the genus Drosophila. The bicoid gradient, which extends across the anterior-posterior axis of Drosophila embryos, organizes the head and thorax.

What is the biological function of the bicoid gene product?

Bicoid (Bcd) controls embryonic gene expression by transcriptional activation and translational repression. Both functions require the homeodomain (HD), which recognizes DNA motifs at target gene enhancers and a specific sequence interval in the 3′ untranslated region of Caudal (CAD) mRNA.

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What does the bicoid gene determine?

Bicoid is a maternal effect gene whose protein concentration gradient patterns the anterior-posterior (A-P) axis during Drosophila embryogenesis. Bicoid was the first protein demonstrated to act as a morphogen.

What would you expect to see in flies that lack the gene that encodes bicoid?

feedback: As expected, lack of Giant or Krüppel results in a broad expression pattern for the second stripe. What would you expect to happen to the pattern of reporter expression in flies that lack the gene encoding Bicoid? a) It would be expressed in all seven stripes.

Where is bicoid expressed?

bicoid is expressed in the anterior egg region, where it exerts its role in patterning the anterior body of the larval fly.

Where is the bicoid gene transcribed?

Bicoid protein enters the nuclei of early-cleavage embryos, where it activates the hunchback gene. The transcription of hunchback is seen only in the anterior half of the embryo —the region where Bicoid protein is found.

What will happen if bicoid is overexpressed?

What do you think happens when BICOID is overexpressed? Nothing, as long as there is an A/P axis, the embryo will develop normally. No, when overexpressed the BICOID gradient shifts. Anterior structures won’t form now because there is too much BICOID.

Is the bicoid gene a cytoplasmic determinant?

Remember, the bicoid mRNA is the cytoplasmic determinant while the Bicoid protein is the morphogen. These experiments prove that bicoid mRNA and thus Bicoid protein are both necessary and sufficient to specify anterior pattern. Bicoid was the first “morphogen” regulating embryonic development to be identified.

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Why are bicoid and Nanos classified as maternal effect genes?

Nanos and Caudal are maternal effect genes that are important in the formation of more posterior abdominal segments of the Drosophila embryo. In embryos from bicoid mutant mothers, the head and thoracic structures are converted to the abdomen making the embryo with posterior structures on both ends, a lethal phenotype.

What important understandings about embryonic development resulted from the research into bicoid?

What important understandings about embryonic development resulted from the research into bicoid? led to the identification of a specific protein required for some of the earliest steps in pattern formation.

Which of the following processes do normal proto oncogenes typically exhibit?

Which of the following processes do normal proto-oncogenes typically exhibit? They stimulate normal cell growth and division.

What is the role of morphogens in development?

Morphogens are substances that establish a graded distribution and elicit distinct cellular responses in a dose dependent manner. They function to provide individual cells within a field with positional information, which is interpreted to give rise to spatial patterns.

How does bicoid mRNA become localized to the anterior pole?

Transport and Anterior Localization of bicoid mRNA in Living Egg Chambers. Following nuclear export, bcd mRNA is transported through the nurse cell cytoplasm to the ring canals, passes through the ring canal junctions into the oocyte, and then localizes to the anterior pole of the oocyte.

What does the presence of bicoid mRNA do to a fruit fly *?

Several experiments in an attempt to understand what determines the anterior and posterior ends of a drosophila larva were done. They isolated fruit flies with mutations in the bicoid gene. This bicoid protein gradient promotes the formation of a gradient of hunchback mRNA and protein along the anterior-posterior axis.

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